KPV
KPV (Lys-Pro-Val) (10mg)
$120USD
Third-Party Tested
Independent lab verified
Batch-Specific CoA
Publicly accessible
YPB.265
Reference number
10mg
Lyophilized vial
C-terminal tripeptide of alpha-MSH. Studied for anti-inflammatory properties in preclinical gut and skin models.
Origin
KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Alpha-MSH was first characterized in the 1950s, and subsequent structure-activity studies identified the C-terminal tripeptide as retaining significant bioactivity independent of the full-length hormone.
Research Lineage
Research by Brzoska, Luger, and colleagues at the University of Munster established the anti-inflammatory properties of alpha-MSH fragments. Work by Dalmasso et al. at Emory University investigated KPV specifically in intestinal epithelial models. The peptide has been studied in colitis, dermatitis, and wound healing preclinical research.
Mechanism of Action
KPV has been observed to inhibit NF-kB activation and reduce pro-inflammatory cytokine expression in cell culture and animal models. Unlike full-length alpha-MSH, it does not appear to signal primarily through melanocortin receptors, suggesting a distinct mechanism of action. Research has investigated its effects on intestinal epithelial barrier integrity and inflammatory cell infiltration.
Structural Notes
Tripeptide. Sequence: Lys-Pro-Val. Molecular weight: 342.43 Da.
Key References
Brzoska T et al. Endocr Rev. 2008;29(5):581-602.
Dalmasso G et al. PLoS One. 2008;3(12):e4044.
Research Use Only. This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for sale to minors.