IGF-DES
IGF-DES (0.1mg)
$140USD
Third-Party Tested
Independent lab verified
Batch-Specific CoA
Publicly accessible
YPB.286
Reference number
0.1mg
Lyophilized vial
Des(1-3)IGF-1. Truncated form of IGF-1 lacking the first three N-terminal amino acids. Higher potency than native IGF-1.
Origin
Des(1-3)IGF-1 is a naturally occurring truncated form of IGF-1 first isolated from porcine uterus and bovine colostrum. Sara et al. and Carlsson-Skwirut et al. identified it in human brain tissue in the late 1980s. The removal of the N-terminal tripeptide (Gly-Pro-Glu) occurs through post-translational processing.
Research Lineage
Ballard et al. at the Cooperative Research Centre for Tissue Growth and Repair in Adelaide characterized the enhanced potency of Des(1-3)IGF-1 relative to full-length IGF-1. Its reduced IGFBP binding was established by Forbes et al. The compound is widely used as a research tool in growth factor biology and cell proliferation studies.
Mechanism of Action
Des(1-3)IGF-1 binds to the IGF-1 receptor with affinity comparable to native IGF-1 but has markedly reduced affinity for IGF binding proteins (particularly IGFBP-3 and IGFBP-5). This results in a higher effective concentration of free peptide and approximately 10-fold greater mitogenic potency in cell culture assays.
Structural Notes
67-amino-acid protein. Native IGF-1 (70 aa) minus the N-terminal tripeptide Gly-Pro-Glu. Molecular weight: ~7,371 Da.
Key References
Ballard FJ et al. Prog Growth Factor Res. 1991;3(1):3-18.
Forbes BE et al. J Biol Chem. 2002;277(30):27554-60.
Research Use Only. This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for sale to minors.